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Availability of data and materials Not applicable Abbreviations ADH: Alcohol dehydrogenase ALDH: Aldehyde dehydrogenase HDL-C: High-density lipoprotein cholesterol LDL-C: Low-density lipoprotein cholesterol TG: Triglyceride MAOA: Monoamine oxidase A COMT: Catechol-o-methyltransferase HSC: Hepatic stellate cells DRD2: Dopamine receptor D2 TAS2R38: Bitter taste receptor CYP2E1: Cytochrome P450, family 2, subfamily E, polypeptide 1 ALDH2: Aldehyde dehydrogenase 2 family ADH1B: Alcohol dehydrogenase class I, beta polypeptide MTTP: Microsome triglyceride transfer protein PPAR-2: Peroxisome proliferator-activated receptors IL-28B: Interleukin-28B APOE: Apolipoprotein E LDLr: Low-density lipoprotein receptor TGF-1: Transforming growth factor-beta 1 COL: Collagenases MMP: Matrix metalloproteinase TNF-: Tumor necrosis factor-alpha NF-B: Nuclear factor-kappa B ROS: Reactive oxygen species MTHFR: Methylenetetrahydrofolate reductase MAT: Methionine adenosyltransferase HCC: Hepatocellular carcinoma BHMT: Betaine homocysteine methyltransferases GSH: Glutathione ATP: Adenosine triphosphate Pi: Inorganic phosphate Chol: Cholesterol LDL: Low-density lipoprotein cholesterol HTG: Intrahepatic triglyceride NASH: Nonalcoholic steatohepatitis TG: Triglyceride VLDL: Very-low-density lipoprotein RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 NFE2L2: Nuclear factor, erythroid 2-like 2 ADH1B: Alcohol dehydrogenase 1B PNPLA3: Patatin-like phospholipase domain-containing 3 DRD2: Dopamine receptor D2 TM6SF2: Transmembrane 6 superfamily member 2 IL-1b: Interleukin 1 beta CYP2E1: Cytochrome P450 family 2 subfamily E member 1 References Rehm J, Samokhvalov AV, Shield KD (2013) Global burden of alcoholic liver diseases

Thats because it can help improve the skin in a number of ways

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In the published case series, one patient was successfully treated with pilocarpine 5 mg daily