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Dehydroepiandrosterone improves hepatic antioxidant systems after renal ischemia-reperfusion injury in rabbits
*Reduction of Oxidative Stress: Helps neutralize free radicals, reducing cell damage and slowing the aging process
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2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation (Tan and Song, 2023),these damages further lead to mitochondrial dysfunction, which in turn prompts more ROS production, forming a positive feedback loop (Tan and Vlajkovic, 2023)
Therefore, direct measurement requires that the IGF-1/IGFBP complex be disrupted
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