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Thymosin beta-4 and its derivatives in tissue repair, immune modulation, and cancer therapy
AEDG, the tetrapeptide commonly referred to as Epithalon/Epitalon, was associated with changes in markers of cell proliferation, tissue-remodeling activity, and programmed cell-death signaling
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In addition to redox imbalance, aging oocytes exhibit progressive genomic instability, deterioration of chromosome cohesion, and reduced efficiency of the spindle assembly checkpoint, all of which increase the risk of meiotic errors and aneuploidy
Together, our findings reveal a direct link between melatonin signaling, immune cell metabolism, and type 2 airway inflammation, and identify the melatonin-NRF2-glutathione axis as a potential therapeutic target in asthma
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