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ATGL, HSL, MGL, lipid-droplet proteins, coactivators, inhibitory proteins, intracellular localization, and substrate accessibility all influence the measured rate of lipid mobilization

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Aging (Albany NY) (2020) This in vivo study by an independent research group demonstrated that FOXO4-DRI clears senescent Leydig cells in the testes of aged mice, resulting in restoration of testosterone secretion to levels approaching those of young animals

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Simultaneously, MMP activity (the enzymes that digest matrix) gets regulated alongside their inhibitors (TIMPs)