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10.1016/j.psyneuen.2020.104687 Psychoneuroendocrinology

The accumulation of senescent cells leads to a buildup of their pro-inflammatory SASP, which, combined with the presence of viable ectopic tissue, drives the vicious cycle of inflammation, fibrosis, and disease progression

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Most data comes from animal studies, so long-term safety and rare side effects remain unclear

Stress management Chronic stress contributes to elevated cortisol levels, which may encourage abdominal fat accumulation in susceptible individuals

The results were perhaps associated with the feedback inhibition of proteases in the duodenum according to Li et al