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Supplementary Movie (download MP4 Non-invasive in vivo fluorescence imaging of ICG 4 -GS-Au25 in PBS-treated and DEM-treated mice
The semaglutide dose varies between these medicationsWegovy is typically prescribed at a higher dose (2.4 mg) for weight loss, while Ozempic is used at lower doses (0.5-1.0 mg) for diabetes
Sources National Library of Medicine, MedlinePlus Semaglutide Injection National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Prescription Medications for Overweight & Obesity
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, was selected as an active-comparator placebo proxy because it was recommended in clinical guidelines as a second-line glucose-lowering therapy, had a similar high cost to the study drugs, showed no effect on cardiovascular outcomes in a large randomized controlled trial and has been validated as a placebo proxy in prior claims-based research 20,41
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