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J Biol Chem 276:4808392, PMID: 11675377 Pandey KB, Rizvi SI (2010) Markers of oxidative stress in erythrocytes and plasma during aging in humans

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While the BBB serves as a barrier to restrict the passage of molecules, the integrity and function of the BBB can be compromised by disease states, disease-caused inflammation, and immune responses in the brain [1, 3, 9], or even systemic infection and inflammation [10] resulting in BBB disruption and greater BBB penetration [11]

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It is the most abundant intracellular antioxidant in human cells and is often called the "master antioxidant" for its central role in redox homeostasis, enzymatic detoxification, and protection against oxidative damage

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