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Theres no recommended upper limit for B12, so overdosing is not a concern

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[1] Pregnancy and breastfeeding are also contraindications

They may notice no difference between semaglutide alone and semaglutide with B12, because there was no deficiency to correct

It has been suggested that dysregulation of this delicate balance alters cortical activity in the frequency range and that measuring drug-induced changes in cortical activity could serve as a non-invasive objective biomarker for predicting the efficacy of pharmacological interventions (231)

Elevated NNMT activity has been associated with obesity, insulin resistance, and reduced metabolic efficiency