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Retatrutide and Tirzepatide are both incretin-receptor-agonist peptides studied in metabolic and obesity-related preclinical research, but they are not interchangeable research tools: Tirzepatide is a dual-receptor agonist, while Retatrutide adds a third receptor target entirely

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Last reviewed: June 17, 2026 Last updated: June 17, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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Fraison E, Kostova E, Moran LJ, Bilal S, Ee CC, Venetis C, Costello MF

is supported by the Natural Sciences and Engineering Research Council of Canada (RGPIN-2022-05058)