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Postmenopausal osteoporosis (type I): After menopause, women experience a sudden drop in estrogen levels, a significant increase in osteoclast activity, accelerated bone resorption, insufficient osteoblast activity, and rapid loss of bone mass (30% -50% loss after 5-10 years of menopause), mainly in the lumbar spine and hip
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Researchers across major Australian research hubs including Sydney, Melbourne, Brisbane, Perth and Adelaide increasingly source high-purity peptide compounds for experimental investigation
More notably, citalopram treatment significantly increased the number of TdT-mediated dUTP nick end labeling (TUNEL)-positive cells, whereas melatonin and vitamin C treatment significantly attenuated citalopram-induced apoptosis
These results support PD as a natural co-therapeutic agent with MTX in 3D HepG2 spheroid models
