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KPV directly inhibits NF-B nuclear translocation via competitive importin-3 binding, suppressing pro-inflammatory cytokine secretion at nanomolar concentrations in cell-based models

(PMID 3169264)

Grover S, Srivastava A, Lee R, Tewari AK, Te AE

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11: Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A, Sikiric S, Bekic D, Penovic T, Drazenovic D, Becejac T, Tepes M, Madzar Z, Novosel L, Beketic Oreskovic L, Oreskovic I, Stupnisek M, Boban Blagaic A, Dobric I

The proportion of p--syn in the normal state is very low, and an abnormal increase in p--syn induces the formation of pathological aggregates that contribute to neurotoxicity [10]