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Found to suppress appetite, Friedman called the hormone 'leptin' after the Greek word for 'thin' (Helmholz-Munich)
J Fam Pract
Evidence shows that the secretion of incretin hormones may be impaired in some patients (particularly secretion of GLP-1 in obese individuals), but the major responsible factor is a loss of beta cell responsiveness to the incretin hormones [4]
If needed, it may be increased slowly over time based on response and tolerance
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