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The rest of the spread is prepayment, not escalation

GLP-1 receptor signaling: effects on pancreatic -cell proliferation and survival

Lee: GLP-1 agonists primarily affect the gastrointestinal system, but they also act on the brain, particularly the hypothalamus, which regulates many core functions, including hormones, temperature, and appetite

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By adding GIP to a GLP-1, the medicine can have a bigger impact on your health than GLP-1 alone