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This enhanced adipose function reduces ectopic lipid deposition in liver and other tissues, indirectly ameliorating hepatic steatosis

Some trials report modest or non-statistically significant results

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Notably, one analysis of the FDA Adverse Event Reporting System (FAERS) looked at reports of sexual dysfunction (including ED, decreased libido, and orgasmic disorders) in men on GLP-1 RAs

Selected Preclinical Data Study 1: Genetic Proof-of-Concept A seminal investigation reported elevated NNMT expression in white adipose tissue (WAT) and liver of obese/diabetic mice

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