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However, because it does not block androgen or progesterone receptors like spironolactone, hormone-related adverse effects such as gynecomastia and menstrual irregularities are expected to occur less frequently

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A pharmacokinetic study in rats found that oral administration produced substantial plasma concentrations, with a maximum concentration of 2252 ng/mL and an elimination half-life of approximately 6.9 hours

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Acknowledgments We thank Editage (www.editage.cn) for its linguistic assistance during the preparation of this manuscript

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