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This kinase activation can initiate intracellular signalling cascades via PI3K/Akt/mTOR or Ras/Raf/MEK/ERK pathways that affect the transcriptional programs associated with cell proliferation, differentiation, protein translation and cellular metabolism (substrate transport) as well as apoptosis
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129 Stabilized -catenin translocates to the nucleus and partners with TCF/LEF transcription factors to activate oncogenic targets, including MYC, Cyclin D1, LGR5, CD44, and ABCB1, genes that regulate proliferation, drug efflux, and stemness
Nelson DB, Tayob N, Nguyen QN, Erasmus J, Mitchell KG, Hofstetter WL, Sepesi B, Antonoff MB , Mehran RJ
Adv Pediatr 33:95126 Gretz N, Manz F, Augustin R, Barrat TM, Bender-Gotze C, Brandis M, Bremer HJ, Brodehl J, Broyer M, Bulla M, Callis L, Chantler C, Diekmann L, Dillon MJ, Egli F, Ehrich JH, Endres W, Fanconi A, Feldhoff C, Geisert J, Gekle D, Gescholl-Bauer B, Grote K, Gruttner R, Hagge W, Haycock CB, Hennemann H, Klare B, Leupold D, Lohr H, Michalk D, Oliveira A, Ott F, Pistor K, Rau J, Scharer K, Schindera F, Schmidt H, Schulte-Wissermann H, Verrier-Jones K, Weber HP, Willenbockel U, Wolf H (1983) Survival time in cystinosis
The time it takes to see a difference before and after glutathione injection can vary person to person
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