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Aging alters the circadian system, particularly melatonin secretion, amplitude, and receptor sensitivity, and these changes affect sleep architecture, metabolism, and cognitive function

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References Adelekan T, Magge S, Shults J, Stallings V, Stettler N (2012) Lipid profiles of children with down syndrome compared with their siblings

Melatonin mediates enhancement of stress tolerance in plants

A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease