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10.1016/j.xphs.2023.02.023
The function of GSH in hepatocytes has been investigated by pharmacological inhibition or genetic ablation of the glutamate-cysteine ligase (GCL), the rate-limiting and regulatory enzyme in GSH biosynthesis
The most significant disruption in the level of ketosis, leading to profound clinical manifestations, occurs in untreated insulin-dependent diabetes mellitus, type 1 diabetes
PMID: 1318377 Ferreira S, Crumb WJ Jr, Carlton CG, Clarkson CW (2001): Effects of Cocaine and Its Major Metabolites on the HERG-Encoded Potassium Channel
It may protect L02 cells from acetaminophen-induced damage by activating the Keap1-Nrf2 antioxidant defense mechanism
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