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It is clinically defined by progressive cognitive decline, particularly in memory, language, executive function, and orientation, which in time culminates in significant loss of independence and diminished quality of life

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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

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