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10,13,66 The outcome is the lack of estradiol and/or agonist SERM actions, which account for the dramatic loss in skin health parameters such as collagen and elastin causing atrophy, wrinkles, poor wound healing/barrier function/hydration

doi: 10.1016/j.bcp.2005.09.021 27

Of course, you wont necessarily get all these benefits right away

Human CD26 expression in transgenic mice affects murine T-cell populations and modifies their subset distribution

Similarly, green tea extract (which carries rare but serious liver injury risk at high doses) and cinnamon (particularly cassia cinnamon, which contains coumarin) have been studied for metabolic effects, but there is no robust evidence they meaningfully enhance incretin hormone activity in humans

Raw milk also seems to provide this benefit because raw milk has a higher concentration of whey proteins compared to pasteurized versions