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Participants who started at 2 mg (lower starting dose) experienced fewer GI side effects than those who started at 4 mg, even when both groups eventually reached the same maintenance dose

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10.2337/diabetes.54.1.146

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While this could reflect healthier control over eating, the researchers note that restraint can also become overly rigid or restrictive in some people, particularly those vulnerable to eating disorders, meaning its long-term implications remain uncertain