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Pattern 2: The Non-Responder (approximately 15% of switchers) Weight loss plateaus or slows despite escalating to Zepbound 12.5 to 15 mg May report initial response at 5 to 7.5 mg that fades by week 16 to 20 Often have underlying metabolic factors (severe insulin resistance, hypothyroidism, medications causing weight gain) For this group, the switch to tirzepatide does not solve the core problem
If fatigue worsens specifically in the 24 to 72 hours after your injection and then improves, it is likely medication-related
However, Ozempic's effect on gastric emptying and potential gastrointestinal side effects warrant consideration
Your healthcare provider will work with you closely to adjust your dose gradually over time and reduce the potential risk of side effects
This applies to patients who fail to achieve individualised glycemic targets despite receiving metformin and an SGLT2 inhibitor (SGLT2i) or who have a contraindication to these medications [16]
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