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Release of presynaptic glutamate and activation of postsynaptic glutamate receptors on the postsynaptic neuron stimulate influx of Na + and Ca 2+ ions into the postsynaptic neuron, which contributes to depolarization and action potentials ( Glutamate Transporters and Receptors Excitatory Amino Acid Transporters Increased levels of extracellular glutamate, particularly asynchronistic glutamate levels, cause cellular damage when excitatory neurotransmission is sufficiently aberrant (Pitt et al., 2000
C., Cengiz, A., & Lawley, S
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Contraindications for treatment with a DPP-4 inhibitor include serious hypersensitivity (e.g., anaphylaxis, angioedema) to a specific DPP-4 inhibitor or any component of the formulation
