Mast cells are immune sentinels that release inflammatory mediators, such as histamine and cytokines, in response to perceived threats
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Am J Physiol Endocrinol Metab 235(1):E88
Importantly, following 48 h of treatment with TGF1 or GHK on lung fibroblasts from former smokers with COPD, we were able to restore this intrinsic defect, which we propose is through organization of the actin cytoskeleton to a contractile phenotype as demonstrated by the confocal images displayed in Figure 6a