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Pediatr Dermatol

A lack of LIFR promotes the nuclear factor B signaling via src homology-2 domain-containing protein tyrosine phosphatase 1, activating the iron-sequestering cytokine lipocalin 2 (LCN2), reducing iron levels, and leading to robust resistance to ferroptosis

This isn't just a minor correlationit suggests that boosting these depleted levels could help restore natural energy production

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Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice

Therefore, the actual sample size of pernicious anemia patients in each study may not reach statistical significance