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The STEP trials evaluated semaglutide and showed average weight reductions of around 15% over 68 weeks, while SURMOUNT trialsfocusing on tirzepatide, a dual GIP/GLP-1 receptor agonistdemonstrated even greater reductions, with participants losing up to 21% of their body weight over 72 weeks (Note: GIP = Glucose-dependent insulinotropic polypeptide)

12,116 Views 56 Download 1 Crossref ABSTRACT Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exhibit not only hypoglycemic effects but also protective effects against nonalcoholic fatty liver disease and cardiovascular diseases, conditions that are associated with dyslipidemia

Oeseburg H, de Boer RA, Buikema H, van der Harst P, van Gilst WH, Sillje HH: Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A

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CagriSema is a combination of semaglutide and the amylin analog cagrilintide

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