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With its once-weekly injection format, Tirzepatide offers a convenient treatment option

Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects

Slower gastric emptying allows better nutrient absorption and reduces post-meal intestinal spasms in some patients

GLP-1: Key to Metabolic Health GLP-1 is a hormone produced in the small intestine that helps regulate key metabolic functions, such as stimulating insulin release, suppressing glucagon, and promoting satiety

Holst highlights the challenges patients face with GLP-1 therapy, particularly regarding long-term use

232,233 GLP-1 inhibits the release of glucagon from -cells through multiple mechanisms