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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines
Accepted clinical thresholds prioritize BMI and related conditions: a BMI 30 typically meets criteria for pharmacologic therapy, while a BMI 27 with qualifying comorbidities may also be eligible
However, these lack controls and often omit baseline nodule data or genetic predisposition
But its not always good news that companies have to deliver to their stakeholders
Do not shake swirl gently
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