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We, therefore, used alternative approaches and have determined the structure of a high molecular weight TrxR subfamily member using cryo-EM, demonstrating the feasibility of this methodology to study this protein subfamily of importance in several human diseases (PDB ID 8A1R, EMD-15084) (Fig

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479 Oxidative stress and ROS signaling associated with iron overload may mediate important factors in cardiac hypertrophy and heart failure

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doi: 10.2337/db07-0648 310 YuXXWattsLMManchemVPChakravartyKMoniaBPMcCalebMLet al