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Roughly 12% experience mild nausea, and injection site reactions are the most common issue
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Some agents, in particular SGLT2i, have been shown to protect organs (heart, kidney) partly independently of their glucose-lowering effect, as this organ protection also occurs in those not affected by type 2 diabetes
Injection site reactions are localized to a small area around the injection point and typically resolve within days
Pharmacogenetic ablation of GLP-1 neurons in the nucleus of the solitary tract (NTS) reduced the GLP-1 content of the spinal cord by almost 80%, indicating that brainstem neurons are the main, if not the only, source of GLP-1 in the spinal cord 9,20
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