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146,147 UC patients have been shown to have significantly diminished gut microbiota diversity, with an increase in the abundance of harmful bacteria and a decrease in the abundance of beneficial bacteria, which affects the immune regulation and inflammatory response of the gut, thereby exacerbating symptoms and promoting the progression of the disease

Side Effects & Safety Nausea 40%+ in clinical trials, most common side effect, usually mild-moderate Flushing facial warmth and redness, typically brief Headache usually mild, resolves within hours Injection site reactions redness, minor swelling Fatigue and dizziness less common Max frequency: Once per 24 hours more frequent dosing increases nausea without additional benefit Pregnancy: Contraindicated (category X) Nausea management: Community sources describe a 500 mcg starting dose taken with light food

The amylin analogue pramlintide was licensed by the FDA in 2005 for patients with insulin-treated diabetes

2023;46(Suppl 1):S15890

Antioxidants work on a cellular level, and the benefits are often gradual

Dark spots and dullness softened