Laboratory findings of markedly elevated B12 levels discovered incidentally should prompt GP review, particularly if you are not taking supplements
[10] [11] Any new or worsening depression, anxiety, or thoughts of self-harm warrant immediate discussion with your healthcare provider
Some people find they reach their goals at 5 mg or 7.5 mg with extended use and never need to escalate to 10 or 15 mg, saving both money and side effect burden
No weight loss at all, nor extra energy
In the SURMOUNT-1 trial, the highest dose led to about 21% mean body-weight loss, more than older single-receptor peptides
Combining them with NAD supplements can amplify the effects, but also potentially increase side effects like hot flashes, nausea, or headaches