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81 In females, Vitamin A, carotenoids, resveratrol, and quercetin have been demonstrated to enhance the activity of endogenous antioxidant enzymes (SOD, CAT, GPx, and GR) in the ovary by stimulating the Nrf2 signaling pathway to increase the expression of these enzymes

Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer

The INTERVAL project performed a comprehensive quantitative assessment of 3,622 plasma proteins in 3,301 healthy participants, revealing 27 genetic variants associated with CAT, 23 with SOD, 22 with GPX, and 14 with GST expression ( p , LD 0.001) ( p , LD 0.001) which included 115,060 individuals ( p , LD 0.001) ( 2.6 Data sources and SNPs selection for osteoporosis The OP dataset was compiled by the MRC-IEU using data from the UK Biobank ( 2.7 Statistical analysis Statistical analyses were conducted using R version 4.3.1 and software packages TwoSampleMR, MRPRESSO, and meta. The Inverse Variance Weighted (IVW) approach was used as the primary analytical method for MR to investigate the causal relationship between genetic variants associated with exposures and the outcome ( p -value 0.05 indicating heterogeneity and requiring the adoption of a Random Effects IVW method

doi: 10.1128/CDLI.7.6.920-924.2000 32 TeskeyG.AbrahemR.CaoR.GyurjianK.IslamogluH.LuceroM.et al

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