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Unknown Long-Term Effects : Long-term risks remain unclear because controlled human studies have not established durable safety outcomes, organ effects, cancer-related concerns, or interaction risks

Targeting HER2 with trastuzumab deruxtecan: a dose-expansion, phase I study in multiple advanced solid tumors

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No study reported long-term IV GSH use

Treatment duration varies by individual and is determined by the prescribing doctor based on progress and goals