346: e8668, doi: Stephens FB, Evans CE, Constantin-Teodosiu D, Greenhaff PL
Im pregnant at 15w
Among the tested formulations, PNP-1-10-0.05 Sema-1.8 mg/mL exhibited the most favorable safety profile across all evaluated tissues, while PNP-1-10-0.05 TZP-4.5 mg/mL, though eliciting a modest increase in localized tissue response, remained substantially more biocompatible than daily bolus TZP
However, aftercare is very important to get the best results and avoid side effects
Combining the AGT targeting siRNA with an ARB led to a stronger hypotensive effect likely because of the concomitant AT2R stimulation
According to the SmPC , gastrointestinal adverse reactions are most frequent during treatment initiation and dose escalation, and tend to diminish over time