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Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III [PMID: 39843801] Laboratory literature summary: Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm

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The researchers noted that patients who were "responders" required significantly higher doses than standard deficiency protocols to maintain their clinical improvements, suggesting a high cellular demand for the nutrient in the face of chronic oxidative stress

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