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According to the DDI guidelines, a compound has the potential to inhibit OATP expression in vivo if the R value is more than 1.1

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8,9 Manifestations Vitamin B 12 deficiency affects multiple systems, and sequelae vary in severity from mild fatigue to severe neurologic impairment 1,2,6,10 (Table 2 4,10 )

Additional markers to consider: oxidative stress markers (8-isoprostane, malondialdehyde), inflammatory markers (hsCRP, IL-6), liver function tests

Metabolic alterations mediated by STAT3 promotes drug persistence in CML