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Another randomized clinical trial is ongoing to assess cardiovascular outcomes in patients with previously established atherosclerotic cardiovascular disease and/or chronic kidney disease treated with oral semaglutide 21

3 Despite this limited direct action on the brain, semaglutide remains highly effective in reducing food intake and body weight, likely due to its peripheral actions and indirect influence on brain pathways

However, the frequency of dulaglutide-related GI side effects dropped off markedly after the first 4-8 weeks, the side effects were mostly mild to moderate in nature, and very few patients dropped out of the study due to GI symptoms, according to Dr

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Significant Weight Loss Patients on Ozempic experience average weight loss of 46kg, making it particularly beneficial for overweight or obese patients with Type 2 diabetes