statins and glp-1 aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner Statins Disrupt Metabolism By Lowering

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NICE recommends GLP-1 receptor agonist medications for adults with type 2 diabetes who haven't achieved adequate glycaemic control with lifestyle changes and other treatments, or for obesity management when specific BMI and comorbidity criteria are met

Limitations of Current Research Many studies are preclinical Human mechanistic trials remain limited Microbiome responses vary individually Diet, sleep, stress, and medications influence outcomes GLP-1 regulation is multi-factorial The microbiome is one variable within a complex endocrine network

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