As a peptide fragment, behaviour may differ from full-length growth hormone in receptor or signalling assays
Later work examined NNMT inhibition combined with dietary changes in obese mice, reporting reductions in body weight, fat mass, and hepatic fat, alongside shifts in gut bacterial populations
Br J Clin Pharmacol 56:635638
Some people may start to feel different within hours of their first injection, while others may require a few weeks and several injections to really start to see a difference
The mechanism does not involve receptor downregulation or tolerance in any known way, but the signal-to-noise ratio is simply too low based on available evidence
To unpack why the mechanism matters for dosing: NNMT sits at a metabolic crossroads