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Be alert for die-off reactions (transient fatigue, headache, GI upset)
10.1021/jacs.9b09782 117 PanP.DongX.ChenY.ZengX.ZhangX.-Z
It is studied in adults with overweight or obesity (BMI 27 or higher in REDEFINE 1) and in adults with type 2 diabetes (REDEFINE 2 and REIMAGINE 2)
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These findings also reinforce the importance of identifying macrophage subtypes that exhibit differential responses to immunotherapy, suggesting that certain subsets may resist reprogramming efforts aimed at converting M2 macrophages into a pro-inflammatory M1 phenotype (163, 164)
For any injectable use, the full monitoring protocol above applies without exception
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