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Hormonal Recovery and System Reset While traditional SERM-based PCT (e.g., Clomid, Nolvadex) may not be necessary after HGH or IGF-1 LR3 alone, users should still support: Liver and metabolic health Insulin sensitivity restoration Endogenous IGF-1 balance Testosterone production (if steroids were included) Prolonged use of IGF-1 analogs may lead to negative feedback on GH/IGF axis and necessitate time off or tapering for hormonal normalization. Baxter, R
It helps the body identify and eliminate harmful substances, ensuring they don't linger and cause long-term cellular damage
What one may experience with Ipamorelin vs Tesamorelin, another may not
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Hormone desensitization Any compound that artificially stimulates hormone release carries theoretical risk of desensitization over time
PMID 25331030)Tier 1 primary [4]Topol, E
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