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The most common adverse effects are gastrointestinal: nausea, vomiting, diarrhea, and constipation
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Forty-two percent of those who were currently using GLP-1s said losing weight on these medications requires the same willpower as traditional methods, and 15% said it takes even more
An initial analysis of the FDA adverse event reporting system (FAERS) data demonstrated no consistent trends in DKA with SGLT2i use over time [39], however an alternative cohort study of 50,220 individuals with type 2 diabetes showed the highest risk of DKA shortly after SGLT2i initiation, which subsequently reduced with time [40]
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