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10.1089/neu.2014.3856 J

Suissa, K., Cromer, S

Humans have less GST activity or 8,9-epoxide conjugation than rats or mice suggesting that humans are less capable of detoxifying this important metabolite [48]

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Cytosolic cysteine comes from only three sources: (1) from methionine via the methionine cycle and the transsulfuration pathway, (2) direct import into the cell from the plasma, and (3) from excess protein catabolism over protein synthesis