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In the solid state, an extended conformation is found, with a trans conformation at the amino end and a gauche conformation at the carboxyl end

Comparing the different versions of GLP-1s, semaglutide is more effective at supporting weight loss than liraglutide

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Once reconstituted in bacteriostatic water, the solution is typically held at 28C and used within the documented stability window

Accessed at www.nejm.org/doi/full/10.1056/NEJMoa2206038

The timing of surgery and whether to continue therapy during the interim requires individualized decision-making