doi: 10.1016/j.rec.2025.02.006 76 RangaswamiJBhallaVde BoerIHStaruschenkoASharpJASinghRRet al
This spatial transcriptomics data of the lung parenchyma from the GeoMx platform were then deconvoluted for the relative abundance of cell types with CibersortX using the in-house single-cell RNA-sequencing defined cell type signatures as references
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The vasodilatory effects are certainly directly related to NO levels while the increased power output may be related to increased cellular supply of the propionate unit which when converted to succinate provides an anaplerotic energy substrate
The observed effects in fibroblast and wound models include stimulation of collagen and glycosaminoglycan synthesis , upregulation of antioxidant pathways, and support for the recruitment of repair cells
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