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A patient returns for follow-up after starting a GLP-1 receptor agonist and mentions something unexpected

TUNEL labeling was performed according to the manufacturers instructions (Roche, 11684817910)

Save Face, a register of accredited practitioners, said it had recorded 90 complaints about the product so far in 2023 50 in the past three months compared with just one complaint in the whole of 2022

Whilst all GLP-1 receptor agonists bind to the same receptor, subtle differences in binding affinity, receptor residence time, and downstream signalling may affect the intensity of gastrointestinal effects