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Complete treatment benefits typically become apparent following three to six months of consistent therapy, with most patients achieving substantial outcomes

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Inhibiting LDHA to reduce lactate synthesis, or developing modulators of p300/HDACs to interfere with the dynamic balance of lactylation has the potential to simultaneously disrupt the metabolic dependency and epigenetic remodeling capabilities of tumors, thereby providing new avenues for combination therapies targeting multiple pathways

Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations