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In preclinical work the fragment has also been linked to angiogenesis (new blood-vessel growth, including VEGF signalling), recruitment of stem and progenitor cells, and reduced inflammation and fibrosis [5] [6]

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The choice of treatment should be individualised, considering the underlying cause, symptom severity, patient preference, and practical factors such as access to healthcare facilities for regular injections

While temperate plants tend to bear the LT stress, various crops like rice, potato, corn, cotton, soyabean and tomato are chilling sensitive plants 17

Short periods outside refrigeration (a few hours) are generally acceptable, but extended exposure to heat degrades the medication