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decades of human data confirm a clean side effect profile
Consistent with this, whole-body GIP receptor deficiency and GIP deficiency protect against obesity induced by long-term high fat feeding in mice [65, 66]
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The study was terminated early by sponsor decision (not safety-related) after completing enrollment of 81 participants in May 2025, though specific efficacy results from this Phase 2 trial are not yet published, with prior Phase 1b data showing the 250mg dose achieved 49% reduction in total MS and clinical response in 8/11 patients versus 0/4 on placebo
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